Count the moves, not just the nights
A two-night weekend can feel short if each day begins with packing and checkout. Choosing one base keeps more time available for the place you came to enjoy. Compare the benefit of another destination with the work of moving there.
A lakeside stay, a beach base or a city neighbourhood can all support this approach. The choice depends on your main activity.
Draw a small circle around your priority
List the one or two outings you care about, then choose accommodation that supports them. Don't pick a room first and discover later that every visit requires a long return journey.
If Lake Bosomtwe is the main reason for your break, compare staying by the lake with travelling from Kumasi each day. Ask about meals and transfers before comparing room prices alone.
Keep departure morning simple
Pack before breakfast if that makes the exit calmer, and leave only a light activity before travelling home. A major excursion on checkout day can create luggage and timing problems.
One base doesn't mean doing the same thing all weekend. It means choosing when to move rather than letting hotel changes decide the rhythm. Add another overnight stop only when it creates a clear benefit you can name.